TY  - JOUR
PY  - 2020//
TI  - Individual susceptibility or resistance to posttraumatic stress disorder-like behaviours
JO  - Behavioural brain research
A1  - Skórzewska, Anna
A1  - Lehner, Małgorzata
A1  - Wisłowska-Stanek, Aleksandra
A1  - Turzyńska, Danuta
A1  - Sobolewska, Alicja
A1  - Krząścik, Paweł
A1  - Szyndler, Janusz
A1  - Maciejak, Piotr
A1  - Chmielewska, Natalia
A1  - Kołosowska, Karolina
A1  - Płaźnik, Adam
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - The aim of this study was to explore the neurobiological background of individual susceptibility and resistance to the development of posttraumatic stress disorder (PTSD)-like behaviours. Rats were divided into susceptible, PTSD(+), and resistant, PTSD(-), groups based on freezing duration during exposure to aversive context and the time spent in the central area in open field test one week after threefold stress experience (modified single prolonged stress). PTSD(-) rats showed increased concentrations of corticosterone in plasma and changes in GAD67 expression: decreased in the infralimbic cortex (IL) and increased in the lateral amygdala (LA), dentate gyrus (DG), and CA1 area of the hippocampus. Moreover, in this group, we found an increase in the number of CRF-positive nuclei in the parvocellular neurons of the paraventricular hypothalamic nucleus (pPVN). The PTSD(+) group, compared to PTSD(-) rats, had decreased concentrations of corticosterone in plasma and reduced CRF expression in the pPVN, higher CRF expression in the CA1, increased expression of CRF-positive nuclei and GR receptors in the CA3 area of the hippocampus, and increased expression of GR receptors in the DG and the central amygdala (CeA). Biochemical analysis showed higher concentrations of noradrenaline, glutamic acid in the dorsal hippocampus and amygdala and lower levels of dopamine and its metabolites in the amygdala of the PTSD(+) group than in the PTSD(-) group. The study revealed different behavioural and biochemical profiles of PTSD(+) and PTSD(-) rats and suggested that individual differences in hypothalamic-pituitary-adrenal (HPA) axis activity may determine hippocampal- and amygdala-dependent memory and fear processing.<br><br>Copyright © 2020. Published by Elsevier B.V.<p />  <p>Language: en</p>
LA  - en
SN  - 0166-4328
UR  - http://dx.doi.org/10.1016/j.bbr.2020.112591
ID  - ref1
ER  -