TY  - JOUR
PY  - 2020//
TI  - The epidemiology of hip fracture among subjects with pyogenic liver abscess (PLA): a nationwide population-based study
JO  - BioMed research international
A1  - Hsu, Chieh-Cheng
A1  - Ko, Jih-Yang
A1  - Lin, Cheng-Li
A1  - Hsu, Horng-Chaung
A1  - Chen, Hsien-Te
A1  - Lin, Che-Chen
A1  - Kuo, Shu-Jui
SP  - e5901962
EP  - e5901962
VL  - 2020
IS  - 
N2  - Pyogenic liver abscess (PLA) is a potentially fatal disease that can stimulate prominent systemic inflammation. Osteoporotic hip fracture is a major complication of systemic inflammation. This study tried to determine the epidemiology of hip fractures among PLA patients. All subjects admitted due to PLA during 1999∼2010 were assessed, excluding the subjects with a history of high energy trauma, malignancy, and previous hip fracture. We matched the control subjects to PLA patients according to age, gender, and the coding of osteoporosis by 1 : 4 ratio. The PLA patients had a 1.17-fold risk of hip fracture than the controls (aHR = 1.17, 95% CI = 1.07-1.29) after adjusting for gender, age, and comorbidities. Considering death as the competing event of suicide, the PLA patients had 1.10-fold suicide risk (aHR = 1.10, 95% CI: 1.00-1.21) than the control subjects under the competing risks regression model. The cumulative incidence of hip fracture was higher in the PLA cohort (log-rank test, <i>p</i> < 0.001). When compared to the controls, the fracture risk was 18.4-fold (aHR = 18.4, 95% CI = 13.0-26.1) for the PLA patients admitted 2-3 times per year and 46.0-fold (aHR = 46.0, 95% CI = 31.2-67.8) for the PLA patients admitted ≧4 times per year. The impact of PLA is more prominent among the subjects aged <45 years (aHR = 2.81, 95% CI = 1.42-5.56). Preventive measures for hip fracture might be warranted for PLA patients.<br><br>Copyright © 2020 Chieh-Cheng Hsu et al.<p />  <p>Language: en</p>
LA  - en
SN  - 2314-6133
UR  - http://dx.doi.org/10.1155/2020/5901962
ID  - ref1
ER  -