TY  - JOUR
PY  - 2019//
TI  - Dietary phytoestrogens modulate aggression and activity in social behavior circuits of male mice
JO  - Hormones and behavior
A1  - Sandhu, Kiran Veer
A1  - Demiray, Yunus Emre
A1  - Yanagawa, Yuchio
A1  - Stork, Oliver
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Phytoestrogens comprise biologically active constituents of human and animal diet that can impact on systemic and local estrogen functions in the brain. Here we report on the importance of dietary phytoestrogens for maintaining activity in a brain circuit controlling aggressive and social behavior of male mice. After six weeks of low-phytoestrogen chronic diet (diadzein plus genistein <20 μg/g) a reduction of intermale aggression and altered territorial marking behavior could be observed, compared to littermates on a standard soy-bean based diet (300 μg/g). Further, mice on low-phyto diet displayed a decrease in sociability and a reduced preference for social odors, indicating a general disturbance of social behavior. Underlying circuits were investigated by analysing the induction of the activity marker c-Fos upon social encounter. Low-phyto diet led to a markedly reduced c-Fos induction in the medial as well as the cortical amygdala, the lateral septum, medial preoptic area and bed nucleus of the stria terminalis. No difference between groups was observed in the olfactory bulb. Together our data suggest that dietary phytoestrogens critically modulate social behavior circuits in the male mouse brain.<br><br>Copyright © 2019 Elsevier Inc. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0018-506X
UR  - http://dx.doi.org/10.1016/j.yhbeh.2019.104637
ID  - ref1
ER  -