TY  - JOUR
PY  - 2019//
TI  - Does early and late life depression differ in residual symptoms, functioning and quality of life among the first-episode major depressive patients
JO  - Asian journal of psychiatry
A1  - Xiao, Le
A1  - Zhou, Jing-Jing
A1  - Feng, Yuan
A1  - Zhu, Xue-Quan
A1  - Wu, Wen-Yuan
A1  - Hu, Yong-Dong
A1  - Niu, Ya-Juan
A1  - Hu, Jian
A1  - Wang, Xue-Yi
A1  - Gao, Cheng-Ge
A1  - Zhang, Ning
A1  - Fang, Yi-Ru
A1  - Liu, Tie-Bang
A1  - Jia, Fu-Jun
A1  - Feng, Lei
A1  - Wang, Gang
SP  - e101843
EP  - e101843
VL  - 47
IS  - 
N2  - AIMS & OBJECTIVES: Age differences exist in many aspects in patients with major depressive disorder (MDD). The present study aims to examine the effect of age on treatment outcomes in first-episode MDD. <br><br>METHODOLOGY: A total of 982 first-episode major depressive patients, who were above 18 years old and admitted in both psychiatric hospitals and units of general hospitals were recruited for the present study. These patients were newly treated and responded to 8-12 weeks of antidepressant treatment. Depressive symptoms, psychosocial functioning and quality of life were measured using standardized instruments. The study population was divided into three age groups: early adult (18-44 years old), middle adult (45-59 years old), and late adult (60-85 years old). <br><br>RESULTS: Earlier age was associated with greater symptom severity, severer depressive symptoms in hypersomnia, concentration/decision making, negative view of the self, suicide ideation and restlessness, more impaired function, poorer satisfaction in social relationship and economic status, when compared to late adults with MDD (all P < 0.05). In the multivariable analyses, among the other variables, early age remained as an independent correlation of residual depressive severity (middle age vs. early age: OR = 0.631, 95%CI[0.462, 0.862]; old age vs. early age: OR = 0.521, 95%CI[0.348, 0.780]) and functional impairment. Comorbidity of physical illness had a negative contribution to all treatment outcomes. <br><br>CONCLUSION: In first major depressive episode, early age was strongly associated with depressive severity and functional impairment after responding to antidepressant treatment. Early-life depression may be an indicator of MDD for poor clinical outcomes and high clinical burden.<br><br>Copyright © 2019 Elsevier B.V. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 1876-2018
UR  - http://dx.doi.org/10.1016/j.ajp.2019.101843
ID  - ref1
ER  -