TY  - JOUR
PY  - 2019//
TI  - Sex differences in cerebral blood flow associated with a history of concussion
JO  - Journal of neurotrauma
A1  - Hamer, Julia
A1  - Churchill, Nathan
A1  - Hutchison, Michael
A1  - Graham, Simon
A1  - Schweizer, Tom A.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Growing evidence suggests that a history of sport concussion may lead to long-term changes in brain physiology, with cerebral blood flow (CBF) being particularly sensitive to injury. However, it is unknown whether these changes are sex-specific. The goal of this study was to evaluate sex differences in CBF in asymptomatic athletes, with and without a history of concussion (HOC) using Arterial Spin Labelling (ASL). Scans were acquired for 122 athletes, including those without prior concussion (33 male, 33 female) and those with HOC (28 male, 28 female). Males with HOC had lower CBF bilaterally than males without HOC, seen predominantly in the temporal lobes. In contrast, females with HOC showed no significant differences relative to females without HOC, although they had significantly higher variability in temporal CBF values compared to males with HOC. Additional analyses within the HOC groups found that females with multiple concussion had lower CBF posteriorly compared to those with a single concussion, whereas males showed no significant effects. This study provides the first evidence of sex differences in CBF associated with HOC.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2019.6800
ID  - ref1
ER  -