TY  - JOUR
PY  - 2019//
TI  - Altered resting-state functional connectivity within the developing social brain after pediatric traumatic brain injury
JO  - Human brain mapping
A1  - Tuerk, Carola
A1  - Dégeilh, Fanny
A1  - Catroppa, Cathy
A1  - Dooley, Julian J.
A1  - Kean, Michael
A1  - Anderson, Vicki
A1  - Beauchamp, Miriam H.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Traumatic brain injury (TBI) in childhood and adolescence can interrupt expected development, compromise the integrity of the social brain network (SBN) and impact social skills. Yet, no study has investigated functional alterations of the SBN following pediatric TBI. This study explored functional connectivity within the SBN following TBI in two independent adolescent samples. First, 14 adolescents with mild complex, moderate or severe TBI and 16 typically developing controls (TDC) underwent resting-state functional magnetic resonance imaging 12-24 months post-injury. Region of interest analyses were conducted to compare the groups' functional connectivity using selected SBN seeds. Then, replicative analysis was performed in an independent sample of adolescents with similar characteristics (9 TBI, 9 TDC). <br><br>RESULTS were adjusted for age, sex, socioeconomic status and total gray matter volume, and corrected for multiple comparisons. Significant between-group differences were detected for functional connectivity in the dorsomedial prefrontal cortex and left fusiform gyrus, and between the left fusiform gyrus and left superior frontal gyrus, indicating positive functional connectivity for the TBI group (negative for TDC). The replication study revealed group differences in the same direction between the left superior frontal gyrus and right fusiform gyrus. This study indicates that pediatric TBI may alter functional connectivity of the social brain. Frontal-fusiform connectivity has previously been shown to support affect recognition and changes in the function of this network could relate to more effortful processing and broad social impairments.<br><br>© 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.<p />  <p>Language: en</p>
LA  - en
SN  - 1065-9471
UR  - http://dx.doi.org/10.1002/hbm.24822
ID  - ref1
ER  -