TY  - JOUR
PY  - 2019//
TI  - Methadone poisonings: a seven year retrospective study of the French Poison Centers Network focusing on suicide attempts versus misuses
JO  - Fundamental and clinical pharmacology
A1  - Torrents, Romain
A1  - Glaizal, Mathieu
A1  - Sinno-Tellier, Sandra
A1  - Richard, Nathalie
A1  - Nisse, Patrick
A1  - Vodovar, Dominique
A1  - Bloch, Juliette
A1  - Simon, Nicolas
A1  - de Haro, Luc
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Methadone has been prescribed in France as opioid substitution therapy as a syrup formulation since 1995 and as capsules since 2008. Following two publications showing on a national scale the high risk of methadone poisoning in children and the lack of difference in poisoning severity between both methadone formulations, French health authorities chose to benefit from the experience acquired by the network of French poison centres concerning poisoning by this substitution medication. The aim of this study was to identify and compare the main circumstances of methadone exposure collected by a poison centre on a national scale over a period of 7 years. Retrospective descriptive study of cases of methadone exposure compiled by the network of French poison centres between October 15, 2010 and October 15, 2017. Analysis of 1415 files revealed two major circumstances: 47% misuse and 41% suicide attempts. Severity scores evaluated according to the PSS were higher for misuse than for suicidal behaviour, despite the supposed ingested dose being statistically higher in the latter. The results also confirmed the lack of significant difference in methadone exposure between both of the formulations (syrup and capsules). This series of methadone exposure on a national scale is one of the largest compiled in international medical literature. On the one hand it highlights the severity of methadone poisoning (in suicidal behaviour and even more so in misuse behaviour), and on the other hand it confirms that the capsule formulation does not seem to represent a higher risk than the syrup formulation. This article is protected by copyright. All rights reserved.<br><br>© 2019 Société Française de Pharmacologie et de Thérapeutique.<p />  <p>Language: en</p>
LA  - en
SN  - 0767-3981
UR  - http://dx.doi.org/10.1111/fcp.12506
ID  - ref1
ER  -