TY  - JOUR
PY  - 2019//
TI  - Genome-wide association studies identify polygenic effects for completed suicide in the Japanese population
JO  - Neuropsychopharmacology
A1  - Otsuka, Ikuo
A1  - Akiyama, Masato
A1  - Shirakawa, Osamu
A1  - Okazaki, Satoshi
A1  - Momozawa, Yukihide
A1  - Kamatani, Yoichiro
A1  - Izumi, Takeshi
A1  - Numata, Shusuke
A1  - Takahashi, Motonori
A1  - Boku, Shuken
A1  - Sora, Ichiro
A1  - Yamamoto, Ken
A1  - Ueno, Yasuhiro
A1  - Toda, Tatsushi
A1  - Kubo, Michiaki
A1  - Hishimoto, Akitoyo
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Suicide is a significant public health problem worldwide, and several Asian countries including Japan have relatively high suicide rates on a world scale. Twin, family, and adoption studies have suggested high heritability for suicide, but genetics lags behind due to difficulty in obtaining samples from individuals who died by suicide, especially in non-European populations. In this study, we carried out genome-wide association studies combining two independent datasets totaling 746 suicides and 14,049 non-suicide controls in the Japanese population. Although we identified no genome-wide significant single-nucleotide polymorphisms (SNPs), we demonstrated significant SNP-based heritability (35-48%; P < 0.001) for completed suicide by genomic restricted maximum-likelihood analysis and a shared genetic risk between two datasets (P<sub>best</sub> = 2.7 × 10<sup>-13</sup>) by polygenic risk score analysis. This study is the first genome-wide association study for suicidal behavior in an East Asian population, and our results provided the evidence of polygenic architecture underlying completed suicide.<p />  <p>Language: en</p>
LA  - en
SN  - 0893-133X
UR  - http://dx.doi.org/10.1038/s41386-019-0506-5
ID  - ref1
ER  -