TY  - JOUR
PY  - 2019//
TI  - Severe acquired brain injury aetiologies, early clinical factors, and rehabilitation outcomes: a retrospective study on pediatric patients in rehabilitation
JO  - Brain injury
A1  - Pozzi, Marco
A1  - Galbiati, Sara
A1  - Locatelli, Federica
A1  - Carnovale, Carla
A1  - Gentili, Marta
A1  - Radice, Sonia
A1  - Strazzer, Sandra
A1  - Clementi, Emilio
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - <b>Objective</b>: Studies on pediatric severe acquired brain injury (sABI) outcomes focused mostly on single etiologies, not clarifying the independent role of clinical factors, and scantly explored inter-dependence between variables. We assessed associations of clinical factors at admission with essential outcomes, controlling for inter-dependence and sABI etiology. <b>Methods</b>: We reviewed the clinical records of 280 patients with traumatic and 292 with non-traumatic sABI, discharged from intensive care to pediatric neurological rehabilitation. We analyzed the distribution of clinical factors based on sABI etiology; conducted a factor analysis of variables; built multivariate models evaluating the associations of variables with death, persistent vegetative states, duration of coma, GOS outcome, length of stay. <b>Results</b>: We described the study sample. Factor analysis of inter-dependence between GCS, time before rehabilitation, dysautonomia, device use, produced the indicators "injury severity" and "neurological dysfunction", independent from sABI etiology, age, sex, and admittance GOS. Multivariate analyzes showed that: coma duration, GOS outcome, and length of stay, which may depend on rehabilitation courses, were directly associated with injury severity, neurological dysfunction, and patients' age; death and persistent vegetative states were also associated with etiology. <b>Conclusion</b>: Future studies should analyze larger cohorts and investigate mechanisms linking specific etiologies and patients' age with outcomes.<p />  <p>Language: en</p>
LA  - en
SN  - 0269-9052
UR  - http://dx.doi.org/10.1080/02699052.2019.1658128
ID  - ref1
ER  -