Maria Semkovska and colleagues 1 did a rigorous meta-analysis of cognitive function in patients remitted from a major depressive episode (MDE). The results suggest that most cognitive variables (55 (73·3%) out of 75 that were analysed) were impaired relative to performance in healthy control participants or normative data, with large effect size differences in a group of variables in the domain of long-term memory. The mediator most commonly associated with poor performance in cognitive variables was the number of previous depressive episodes (25 [33·3%] of the 75 variables). The analysis adds to the substantial body of literature suggesting that cognitive deficits persist in some patients after resolution of most other symptoms following an MDE, and that the magnitude of the deficit relates to the number of episodes experienced...
Language: en
LA - en SN - 2215-0374 UR - http://dx.doi.org/10.1016/S2215-0366(19)30278-0 ID - ref1 ER -