TY  - JOUR
PY  - 2019//
TI  - Reduced neuron-specific enolase levels in chronic severe traumatic brain injury
JO  - Journal of neurotrauma
A1  - Bagnato, Sergio
A1  - Andriolo, Maria
A1  - Boccagni, Cristina
A1  - Lucca, Lucia Francesca
A1  - De Tanti, Antonio
A1  - Pistarini, Caterina
A1  - Barone, Teresa
A1  - Galardi, Giuseppe
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Growing evidence suggests that pathophysiological mechanisms leading to neurodegeneration and neuronal loss take place during the chronic phase of a severe traumatic brain injury (TBI). In this study we evaluated a well-established marker of brain injury, the neuron-specific enolase (NSE), in the serum of 51 patients with severe TBI (86% males, mean age 33.8 ± 11.1 years). All patients' samples were available from a previous study and the mean time between TBI and blood sample collection was 23.2 ± 31.5 months (28 patients were evaluated within 12 months of TBI and 23 patients 12+ months after TBI). Patients' NSE levels were compared with those obtained from 30 age and sex-matched healthy controls (87% males, 33.7 ± 11.3 years). We found that NSE levels were significantly lower in patients (median 3.2 ng/ml; 25th, 75th percentile 2.5, 5.1) than in healthy controls (median 4.1 ng/ml; 25th, 75th percentile 3.1, 7.5) (p = 0.026). This finding was mainly driven by data from the chronic patients, i.e. those who suffered their TBI at least 12 months before the evaluation. Indeed, these patients had significantly lower NSE levels (median 2.6 ng/ml; 25th, 75th percentile 1.9, 4) than healthy controls (p < 0.01). On the contrary, NSE levels evaluated in patients less than 12 months from TBI (median 3.9 ng/ml; 25th, 75th percentile 2.8, 5.7) did not significantly differ from controls (p = 0.3). These findings possibly reflect a progressive brain atrophy with reduced baseline NSE release in the chronic phase of a severe TBI.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2019.6449
ID  - ref1
ER  -