TY  - JOUR
PY  - 2019//
TI  - Resting-state fMRI metrics in acute sport-related concussion and their association with clinical recovery: a study from the NCAA-DOD CARE Consortium
JO  - Journal of neurotrauma
A1  - Meier, Timothy
A1  - Giraldo-Chica, Monica
A1  - Espana, Lezlie
A1  - Mayer, Andrew
A1  - Harezlak, Jaroslaw
A1  - Nencka, Andrew S.
A1  - Wang, Yang
A1  - Koch, Kevin M.
A1  - Wu, Yu-Chien
A1  - Saykin, Andrew J.
A1  - Giza, Christopher C.
A1  - Goldman, Joshua
A1  - Difiori, John P.
A1  - Guskiewicz, Kevin K.
A1  - Mihalik, Jason
A1  - Brooks, Alison
A1  - Broglio, Steven P.
A1  - McAllister, Thomas
A1  - McCrea, Michael
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - There has been a recent call for longitudinal cohort studies to track the physiological recovery of sport-related concussion (SRC) and its relationship with clinical recovery. Resting-state fMRI (rs-fMRI) has shown potential for detecting subtle changes in brain function after SRC. We investigated the effects of SRC on rs-fMRI metrics assessing local connectivity (regional homogeneity; REHO), global connectivity (average nodal strength), and the relative amplitude of slow oscillations of rs-fMRI (fractional amplitude of low frequency fluctuations; fALFF). Athletes diagnosed with SRC (N=92) completed visits with neuroimaging at 24-48 hours post-injury (24-hours), after clearance to begin the return-to-play (RTP) progression (asymptomatic), and seven days following unrestricted RTP (post-RTP). Non-injured athletes (N=82) completed visits yoked to the schedule of matched injured athletes and served as controls. Concussed athletes had elevated symptoms, worse neurocognitive performance, greater balance deficits, and elevated psychological symptoms at the 24-hour visit relative to controls. These deficits were largely recovered by the asymptomatic visit. Concussed athletes still reported elevated psychological symptoms at the asymptomatic visit relative to controls. Concussed athletes also had elevated REHO in the right middle and superior frontal gyri at the 24-hour visit that returned to normal levels by the asymptomatic visit. Additionally, REHO in these regions at 24-hours predicted psychological symptoms at the asymptomatic visit in concussed athletes. Current results suggest that SRC is associated with an acute alteration in local connectivity that follows a similar time course as clinical recovery. Our results do not indicate strong evidence that concussion-related alterations in rs-fMRI persist beyond clinical recovery.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2019.6471
ID  - ref1
ER  -