TY  - JOUR
PY  - 2019//
TI  - Migraine and traumatic brain injury: a cohort study in Taiwan
JO  - BMJ open
A1  - Wang, Qing-Rui
A1  - Lu, Ying-Yi
A1  - Su, Ying-Ju
A1  - Qin, Hao
A1  - Zhang, Li
A1  - Wu, Ming-Kung
A1  - Zhang, Cong-Liang
A1  - Wu, Chieh-Hsin
SP  - e027251
EP  - e027251
VL  - 9
IS  - 7
N2  - OBJECTIVE: Traumatic brain injury is now a major contributor to the global healthcare burden. Migraine is another debilitating disease with a global health impact. While most researchers agree that traumatic brain injury is a risk factor for migraine, whether migraine is a risk factor for traumatic brain injury still remains under debate. We therefore aimed to investigate whether migraine was a risk factor for developing traumatic brain injury. STUDY DESIGN: Retrospective population-based cohort study. SETTING: Data for people who had been diagnosed with migraine were retrieved from Taiwan's National Health Insurance Research Database. PARTICIPANTS: We identified 7267 patients with newly diagnosed migraine during 1996-2010. The migraineurs to non-migraineurs ratio was set at 1:4 to enhance the power of statistical tests. PRIMARY AND SECONDARY OUTCOME MEASURES: We used multivariate Cox proportional hazard regression models to assess the effects of migraines on the risk of traumatic brain injury after adjusting for potential confounders. <br><br>RESULTS: The overall traumatic brain injury risk was 1.78 times greater in the migraine group compared with the non-migraine group after controlling for covariates. Additionally, patients with previous diagnoses of alcohol-attributed disease, mental disorders and diabetes mellitus had a significantly higher traumatic brain injury risk compared with those with no history of these diagnoses. <br><br>CONCLUSIONS: This study of a population-based database indicated that migraine is a traumatic brain injury risk factor. Greater attention to migraine-targeted treatment modalities may reduce traumatic brain injury-related morbidity and mortality.<br><br>© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.<p />  <p>Language: en</p>
LA  - en
SN  - 2044-6055
UR  - http://dx.doi.org/10.1136/bmjopen-2018-027251
ID  - ref1
ER  -