TY  - JOUR
PY  - 2019//
TI  - Mood and suicidality outcomes 3-11 years following pediatric anxiety disorder treatment
JO  - Depression and anxiety
A1  - Keeton, Courtney P.
A1  - Caporino, Nicole E.
A1  - Kendall, Philip C.
A1  - Iyengar, Satish
A1  - Lee, Phyllis
A1  - Peris, Tara
A1  - Sakolsky, Dara
A1  - Piacentini, John
A1  - Compton, Scott N.
A1  - Albano, Anne Marie
A1  - Birmaher, Boris
A1  - Ginsburg, Golda S.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: Youth anxiety interventions have potential to reduce risk for depression and suicidality. <br><br>METHODS: This naturalistic follow-up of the multi-site, comparative treatment trial, inking and behavior, and depressive symptoms 3-11 years (mean 6.25 years) following 12-week evidence-based youth anxiety treatment. Participants (N = 319; 10-26 years, mean 17 years) completed semiannual questionnaires and annual diagnostic interviews for 4 years. <br><br>RESULTS: One-fifth (20.4%) of the sample met DSM-IV criteria for a mood disorder, 32.1% endorsed suicidal ideation, and 8.2% reported suicidal behavior. Latent class growth analysis yielded two linear trajectories of depressive symptoms, and 85% of the sample demonstrated a persistent low-symptom course over seven assessments. Child/Adolescent Anxiety Multimodal Study (CAMS) 12-week treatment outcome (positive response, remission) and treatment condition (cognitive behavior therapy [CBT], medication, CBT + medication, pill placebo) were not associated with subsequent mood disorder or suicidal thinking. CAMS remission predicted absence of suicidal behavior, and treatment response and remission predicted low depressive symptom trajectory. Greater baseline self-reported depressive symptoms predicted all long-term mood outcomes, and more negative life events predicted subsequent mood disorder, depressive symptom trajectory, and suicidal ideation. <br><br>CONCLUSIONS: Effective early treatment of youth anxiety, including CBT, medication, or CBT + medication, reduces risk for subsequent chronic depressive symptoms and suicidal behavior. Attention to (sub)clinical depressive symptoms and management of negative life events may reduce odds of developing a mood disorder, chronic depressive symptoms, and suicidality. <br><br>FINDINGS contribute to evidence that early intervention for a primary disorder can serve as secondary prevention.<br><br>© 2019 Wiley Periodicals, Inc.<p />  <p>Language: en</p>
LA  - en
SN  - 1091-4269
UR  - http://dx.doi.org/10.1002/da.22944
ID  - ref1
ER  -