TY  - JOUR
PY  - 2019//
TI  - Herb-induced liver injury: phylogenetic relationship, structure-toxicity relationship, and herb-ingredient network analysis
JO  - International journal of molecular sciences
A1  - He, Shuaibing
A1  - Zhang, Chenyang
A1  - Zhou, Ping
A1  - Zhang, Xuelian
A1  - Ye, Tianyuan
A1  - Wang, Ruiying
A1  - Sun, Guibo
A1  - Sun, Xiaobo
SP  - e20153633
EP  - e20153633
VL  - 20
IS  - 15
N2  - Currently, hundreds of herbal products with potential hepatotoxicity were available in the literature. A comprehensive summary and analysis focused on these potential hepatotoxic herbal products may assist in understanding herb-induced liver injury (HILI). In this work, we collected 335 hepatotoxic medicinal plants, 296 hepatotoxic ingredients, and 584 hepatoprotective ingredients through a systematic literature retrieval. Then we analyzed these data from the perspectives of phylogenetic relationship and structure-toxicity relationship. Phylogenetic analysis indicated that hepatotoxic medicinal plants tended to have a closer taxonomic relationship. By investigating the structures of the hepatotoxic ingredients, we found that alkaloids and terpenoids were the two major groups of hepatotoxicity. We also identified eight major skeletons of hepatotoxicity and reviewed their hepatotoxic mechanisms. Additionally, 15 structural alerts (SAs) for hepatotoxicity were identified based on SARpy software. These SAs will help to estimate the hepatotoxic risk of ingredients from herbs. Finally, a herb-ingredient network was constructed by integrating multiple datasets, which will assist to identify the hepatotoxic ingredients of herb/herb-formula quickly. In summary, a systemic analysis focused on HILI was conducted which will not only assist to identify the toxic molecular basis of hepatotoxic herbs but also contribute to decipher the mechanisms of HILI.<p />  <p>Language: en</p>
LA  - en
SN  - 1661-6596
UR  - http://dx.doi.org/10.3390/ijms20153633
ID  - ref1
ER  -