TY  - JOUR
PY  - 2002//
TI  - Topical administration of low-dose tenofovir disoproxil fumarate to protect infant macaques against multiple oral exposures of low doses of simian immunodeficiency virus
JO  - Journal of infectious diseases
A1  - Van Rompay, Koen K. A.
A1  - Schmidt, Kimberli A.
A1  - Lawson, Jonathan R.
A1  - Singh, Raman
A1  - Bischofberger, Norbert
A1  - Marthas, Marta L.
SP  - 1508
EP  - 1513
VL  - 186
IS  - 10
N2  - Simian immunodeficiency virus (SIV) infection of infant macaques is a useful animal model to determine whether topical (oral) administration of antiviral compounds to the nursing infant could reduce human immunodeficiency virus transmission through breast-feeding. The reverse-transcriptase inhibitor tenofovir was selected because of previous demonstrations that systemic drug levels are effective in preventing SIV infection. To mimic the multiple exposures to virus during breast-feeding, 14 infant macaques were fed 15 low doses of SIVmac251 without chemical restraint. Six animals were treated with placebo, and 2 groups of 4 animals received oral topical doses of tenofovir disoproxil fumarate (DF; equivalent to 0.037 mg of tenofovir/day). About half the animals of each group became infected. In a subsequent study, 2 oral inoculations of 4 juvenile macaques with a mixture of tenofovir DF and SIVmac251 induced persistent infection. Topical administration of low doses of tenofovir DF did not protect against oral SIV infection.<p /> <p>Language: en</p>
LA  - en
SN  - 0022-1899
UR  - http://dx.doi.org/10.1086/344360
ID  - ref1
ER  -