TY  - JOUR
PY  - 2008//
TI  - Pregnancy complications associated with hepatitis C: data from a 2003-2005 Washington state birth cohort
JO  - American journal of obstetrics and gynecology
A1  - Pergam, Steven A.
A1  - Wang, Chia C.
A1  - Gardella, Carolyn M.
A1  - Sandison, Taylor G.
A1  - Phipps, Warren T.
A1  - Hawes, Stephen E.
SP  - 38.e1
EP  - 389
VL  - 199
IS  - 1
N2  - OBJECTIVE: The objective of the study was to determine the effect of hepatitis C virus (HCV) on selected maternal and infant birth outcomes. STUDY DESIGN: This population-based cohort study using Washington state birth records from 2003 to 2005 compared a cohort of pregnant women identified as HCV positive from birth certificate data (n = 506) to randomly selected HCV-negative mothers (n = 2022) and drug-using HCV-negative mothers (n = 1439). <br><br>RESULTS: Infants of HCV-positive mothers were more likely to be low birthweight (odds ratio [OR], 2.17; 95% confidence interval [CI] 1.24, 3.80), to be small for gestational age (OR, 1.46; 95% CI, 1.00, 2.13), to need assisted ventilation (OR, 2.37; 95% CI, 1.46, 3.85), and to require neonatal intensive car unit (NICU) admission (OR, 2.91; 95% CI, 1.86, 4.55). HCV-positive mothers with excess weight gain also had a greater risk of gestational diabetes (OR, 2.51; 95% CI, 1.04, 6.03). Compared with the drug-using cohort, NICU admission and the need for assisted ventilation remained associated with HCV. <br><br>CONCLUSION: HCV-positive pregnant women appear to be at risk for adverse neonatal and maternal outcomes.<p /> <p>Language: en</p>
LA  - en
SN  - 0002-9378
UR  - http://dx.doi.org/10.1016/j.ajog.2008.03.052
ID  - ref1
ER  -