TY  - JOUR
PY  - 2019//
TI  - The role of TaqI DRD2 (rs1800497) and DRD4 VNTR polymorphisms in posttraumatic stress disorder (PTSD)
JO  - Psychiatria Danubina
A1  - Hoxha, Blerina
A1  - Goçi Uka, Afërdita
A1  - Agani, Ferid
A1  - Haxhibeqiri, Shpend
A1  - Haxhibeqiri, Valdete
A1  - Sabic Dzananovic, Emina
A1  - Kučukalić, Sabina
A1  - Bravo Mehmedbasic, Alma
A1  - Kucukalic, Abdulah
A1  - Dzubur Kulenovic, Alma
A1  - Feric Bojic, Elma
A1  - Marjanovic, Damir
A1  - Kravic, Nermina
A1  - Avdibegovic, Esmina
A1  - Muminovic Umihanić, Mirnesa
A1  - Jakšić, Nenad
A1  - Cima Franc, Ana
A1  - Rudan, Dusko
A1  - Jakovljević, Miro
A1  - Babić, Romana
A1  - Pavlović, Marko
A1  - Babic, Dragan
A1  - Aukst Margetić, Branka
A1  - Bozina, Nada
A1  - Sinanovic, Osman
A1  - Ziegler, Christiane
A1  - Warrings, Bodo
A1  - Domschke, Katharina
A1  - Deckert, Jürgen
A1  - Wolf, Christiane
A1  - Vyshka, Gentian
SP  - 263
EP  - 268
VL  - 31
IS  - 2
N2  - BACKGROUND: Posttraumatic stress disorder (PTSD) is a complex stress related disorder, that follows a severe traumatic experience, characterized with an intense sense of terror, fear, and helplessness. The aim of this study is to identify associations of genetic variations within candidate genes DRD2 and DRD4 with various PTSD related phenotypes. PTSD lifetime and PTSD current subjects were analyzed separately, each of them were analyzed in a Case/Control design, as well as regarding BSI and CAPS within cases only. <br><br>SUBJECTS AND METHODS: 719 (487 male, 232 female) participants who had experienced war-related trauma between 1991 and 1999 in Bosnia and Hercegovina, Kosovo and Croatia were included in the study. Sociodemographic questionnaire, Clinician Administered PTSD Scale (CAPS) and the Brief Symptom Inventory (BSI) were used to collect clinical data. <br><br>RESULTS: The DRD2 rs1800497 variant and a variable number tandem repeat (VNTR) located in exon three of DRD4 were investigated for association with PTSD. In case control analyses we did not identify any significant associations. Within the PTSD current patients, we identified an association of DRD2 rs1800497 with BSI in the genotypic and the recessive model with the T allele as the risk allele. <br><br>CONCLUSION: Our findings suggest that rs1800497 of DRD2 gene is involved in pathogenesis of PTSD.<p />  <p>Language: en</p>
LA  - en
SN  - 0353-5053
UR  - http://dx.doi.org/10.24869/psyd.2019.263
ID  - ref1
ER  -