TY - JOUR PY - 2019// TI - Necrotizing mucormycosis of wounds following combat injuries, natural disasters, burns, and other trauma JO - Journal of fungi (Basel) A1 - Walsh, Thomas J. A1 - Hospenthal, Duane R. A1 - Petraitis, Vidmantas A1 - Kontoyiannis, Dimitrios P. SP - e5030057 EP - e5030057 VL - 5 IS - 3 N2 - Necrotizing mucormycosis is a devastating complication of wounds incurred in the setting of military (combat) injuries, natural disasters, burns, or other civilian trauma. Apophysomyces species, Saksenaea species and Lichtheimia (formerly Absidia) species, although uncommon as causes of sinopulmonary mucormycosis, are relatively frequent agents of trauma-related mucormycosis. The pathogenesis of these infections likely involves a complex interaction among organism, impaired innate host defenses, and biofilms related to traumatically implanted foreign materials. Effective management depends upon timely diagnosis, thorough surgical debridement, and early initiation of antifungal therapy.

Language: en

LA - en SN - 2309-608X UR - http://dx.doi.org/10.3390/jof5030057 ID - ref1 ER -