TY  - JOUR
PY  - 2019//
TI  - Mortality among people with regular or problematic use of amphetamines: a systematic review and meta-analysis
JO  - Addiction
A1  - Stockings, Emily
A1  - Tran, Lucy Thi
A1  - Santo, Thomas
A1  - Peacock, Amy
A1  - Larney, Sarah
A1  - Santomauro, Damian
A1  - Farrell, Michael
A1  - Degenhardt, Louisa
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND AND AIMS: Amphetamines are the second most commonly used class of illicit drugs. We aimed to produce pooled estimates of mortality risks among people with regular or dependent use of amphetamines, with a focus upon all-cause mortality as well as specific causes of death. <br><br>DESIGN: Systematic review and meta-analysis of cohorts of people with problematic use or dependence on amphetamines with data on all-cause or cause-specific mortality. SETTING AND PARTICIPANTS: Of 4,240 papers, 30 were eligible, reporting on 25 cohorts that measured all-cause mortality, drug poisoning, suicide, accidental injuries, homicide and cardiovascular mortality. Cohorts (n=35-74,139) were in North America, several Nordic countries, and Asia-Pacific. MEASUREMENT: Titles/abstracts were independently screened by one reviewer and excluded ones reviewed by a second. Full-text screening was by two reviewers with discrepancies resolved via a third reviewer. We extracted data on crude mortality rates (CMR) per 100-person-years (PY), standardised mortality ratios (SMRs). We imputed SMRs where possible if not reported by study authors. We also calculated mortality relative risks. Data were pooled using random-effects models; potential reasons for heterogeneity were explored using subgroup analyses and meta-regressions. <br><br>FINDINGS: Twenty-three cohorts contributed data for the pooled all-cause CMR: 1.11 per 100PY (95%CI 0.90-1.37). Pooled cause-specific mortality rates were: drug poisoning, 0.14 per 100PY (95%CI: 0.06-0.34); cardiovascular disease, 0.13 per 100PY (95%CI: 0.06-0.55); suicide, 0.20 per 100PY (95%CI: 0.07-0.55); accidental injury, 0.20 per 100PY (95%CI: 0.08-0.47) and homicide, 0.03 per 100PY (95%CI: 0.02-0.06). There was substantial heterogeneity for all pooled CMR estimates except homicide. The pooled all-cause SMR was 6.83 (95%CI: 5.27-8.84). Pooled cause-specific SMRS were: poisoning, 24.70 (95%CI: 16.67, 36.58); homicide, 11.90 (95%CI: 7.82-18.12); suicide, 12.20 (95%CI: 4.89-30.47); cardiovascular disease, 5.12 (95%CI: 3.74-7.00) and accidental injury, 5.12 (95%CI: 2.88-9.08). <br><br>CONCLUSIONS: People with regular or dependent amphetamine use are at elevated risk of a range of causes of mortality compared with people without regular or dependent amphetamine use.<br><br>This article is protected by copyright. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0965-2140
UR  - http://dx.doi.org/10.1111/add.14706
ID  - ref1
ER  -