TY  - JOUR
PY  - 2019//
TI  - Base excess in predicting the prognosis of patients with paraquat poisoning: A meta-analysis
JO  - Medicine (Baltimore)
A1  - Zhang, Feng Wei
A1  - Gao, Jie
A1  - Zhang, Su Li
A1  - Wu, Cheng Pu
A1  - Li, Yong
A1  - Bai, Wen Jing
A1  - Feng, Shun Yi
SP  - e15973
EP  - e15973
VL  - 98
IS  - 23
N2  - BACKGROUND: Although the prognostic significance of base excess (BE) in patients with paraquat (PQ) poisoning has been investigated for several years, the results remain controversial. Thus, we performed for the first time a comprehensive meta-analysis to explore the value of BE in predicting the prognosis of patients with PQ poisoning. <br><br>METHODS: We searched PubMed, EMBase, Web of Science, ScienceDirect, Cochrane Library, and the Chinese National Knowledge Infrastructure to identify all relevant papers that were published up to August 2018. The data were extracted for pooled analysis, heterogeneity testing, sensitivity analysis, publication bias analysis, and subgroup analysis. <br><br>RESULTS: Pooled analysis revealed that a decreased BE is correlated with poor mortality (pooled OR = 21.358, 95% CI: 12.716-35.873, P < .001). Pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were 78% (95% CI: 0.66-0.86), 88% (95% CI: 0.66-0.97), 6.6 (95% CI: 2.2-19.9), 0.25 (95% CI: 0.18-0.36), and 26 (10-69), respectively. No publication bias was detected by Egger test (P = .263) and Begg test (P = .462). Sensitivity analyses indicated no important differences among the estimates of effects. <br><br>CONCLUSION: Our findings show that BE is useful for predicting the prognosis of PQ poisoning.<p />  <p>Language: en</p>
LA  - en
SN  - 0025-7974
UR  - http://dx.doi.org/10.1097/MD.0000000000015973
ID  - ref1
ER  -