TY  - JOUR
PY  - 1978//
TI  - Acetaminophen overdose: incidence, diagnosis, and management in 416 patients
JO  - Pediatrics
A1  - Rumack, B. H.
A1  - Peterson, R. G.
SP  - 898
EP  - 903
VL  - 62
IS  - 5 Pt 2 Suppl
N2  - Acetaminophen overdose was studied in 416 patients as part of a nationwide multiclinic open study. Twenty-seven percent of the patients were toxic by plasma acetaminophen level. The 12- to 21-year-old age group had the highest incidence of toxic blood levels (47%). Children under age 5 had the mildest toxicity of any age group; only two of 16 patients had toxic blood levels. No relationship to subsequent Reye's syndrome could be demonstrated. Acetylcysteine is a safe, effective treatment if administered within the first ten hours; it has some efficacy with no toxicity if used after ten hours. Acetylcysteine has advantages over both cysteamine and methionine. All patients in this study recovered with no sequelae.<p />  <p>Language: en</p>
LA  - en
SN  - 0031-4005
UR  - http://dx.doi.org/
ID  - ref1
ER  -