TY  - JOUR
PY  - 2019//
TI  - Resting-state amplitude of low-frequency fluctuation is associated with suicidal ideation
JO  - Depression and anxiety
A1  - Lan, Martin J.
A1  - Rizk, Mina M.
A1  - Pantazatos, Spiro P.
A1  - Rubin-Falcone, Harry
A1  - Miller, Jeffrey M.
A1  - Sublette, M. Elizabeth
A1  - Oquendo, Maria A.
A1  - Keilp, John G.
A1  - Mann, J. John
SP  - 433
EP  - 441
VL  - 36
IS  - 5
N2  - BACKGROUND: Identifying brain activity patterns that are associated with suicidal ideation (SI) may help to elucidate its pathogenesis and etiology. Suicide poses a significant public health problem, and SI is a risk factor for suicidal behavior. <br><br>METHODS: Forty-one unmedicated adult participants in a major depressive episode (MDE), 26 with SI on the Beck Scale for Suicidal Ideation and 15 without SI, underwent resting-state functional magnetic resonance imaging scanning. Twenty-one healthy volunteers (HVs) were scanned for secondary analyses. Whole brain analysis of both amplitude of low-frequency fluctuations (ALFFs) and fractional ALFF was performed in MDE subjects to identify regions where activity was associated with SI. <br><br>RESULTS: Subjects with SI had greater ALFF than those without SI in two clusters: one in the right hippocampus and one in the thalamus and caudate, bilaterally. Multi-voxel pattern analysis distinguished between those with and without SI. Post hoc analysis of the mean ALFF in the hippocampus cluster found it to be associated with a delayed recall on the Buschke memory task. Mean ALFF from the significant clusters was not associated with depression severity and did not differ between MDE and HV groups. <br><br>DISCUSSION: These results indicate that SI is associated with altered resting-state brain activity. The pattern of elevated activity in the hippocampus may be related to how memories are processed.<br><br>© 2019 Wiley Periodicals, Inc.<p />  <p>Language: en</p>
LA  - en
SN  - 1091-4269
UR  - http://dx.doi.org/10.1002/da.22888
ID  - ref1
ER  -