TY  - JOUR
PY  - 2019//
TI  - Neuromodulation strategies in post-traumatic stress disorder: from preclinical models to clinical applications
JO  - Brain sciences
A1  - Gouveia, Flavia V.
A1  - Gidyk, Darryl C.
A1  - Giacobbe, Peter
A1  - Ng, Enoch
A1  - Meng, Ying
A1  - Davidson, Benjamin
A1  - Abrahao, Agessandro
A1  - Lipsman, Nir
A1  - Hamani, Clement
SP  - e9020045
EP  - e9020045
VL  - 9
IS  - 2
N2  - Post-traumatic stress disorder (PTSD) is an often debilitating disease with a lifetime prevalence rate between 5⁻8%. In war veterans, these numbers are even higher, reaching approximately 10% to 25%. Although most patients benefit from the use of medications and psychotherapy, approximately 20% to 30% do not have an adequate response to conventional treatments. Neuromodulation strategies have been investigated for various psychiatric disorders with promising results, and may represent an important treatment option for individuals with difficult-to-treat forms of PTSD. We review the relevant neurocircuitry and preclinical stimulation studies in models of fear and anxiety, as well as clinical data on the use of transcranial direct current stimulation (tDCS), repetitive transcranial magnetic stimulation (rTMS), and deep brain stimulation (DBS) for the treatment of PTSD.<p />  <p>Language: en</p>
LA  - en
SN  - 2076-3425
UR  - http://dx.doi.org/10.3390/brainsci9020045
ID  - ref1
ER  -