TY  - JOUR
PY  - 2019//
TI  - Postmortem findings of pipamperone after fatal intoxications and its distribution in body fluids and tissues
JO  - Drug testing and analysis
A1  - Henning, Katarina
A1  - Teske, Jorg
A1  - Klintschar, Michael
A1  - Dziadosz, Marek
SP  - 626
EP  - 630
VL  - 11
IS  - 4
N2  - Three cases of fatal intoxication after self-administered pipamperone are reported. The case histories and especially the toxicological findings along with a description of the analytical method are presented. Detection and quantification were performed by liquid chromatography-electrospray-mass spectrometry. Femoral blood concentrations were quantified at 15-39 μg/mL. Besides that, the concentrations of pipamperone in heart blood (15-51 μg/mL), urine (445-548 μg/mL), bile (70-339 μg/mL), liver (91-190 μg/g), kidney (37-74 μg/g), lung (54-227 μg/g) and brain (41-113 μg/g) can be classified as toxic so that the results are most likely in accordance with fatal intoxication especially caused by pipamperone. Besides pipamperone, further pharmaceuticals and ethanol were proven and are stated sorted by the cases. The distribution of pipamperone in the body fluids and tissues is presented. For the first time, this study presents fatal intoxications which were most likely induced by self-administered pipamperone. Furthermore, the data provides a first insight on the distribution of pipamperone.<br><br>This article is protected by copyright. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 1942-7603
UR  - http://dx.doi.org/10.1002/dta.2574
ID  - ref1
ER  -