TY  - JOUR
PY  - 2019//
TI  - Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
JO  - Nature genetics
A1  - Karlsson Linnér, Richard
A1  - Biroli, Pietro
A1  - Kong, Edward
A1  - Meddens, S. Fleur W.
A1  - Wedow, Robbee
A1  - Fontana, Mark Alan
A1  - Lebreton, Maël
A1  - Tino, Stephen P.
A1  - Abdellaoui, Abdel
A1  - Hammerschlag, Anke R.
A1  - Nivard, Michel G.
A1  - Okbay, Aysu
A1  - Rietveld, Cornelius A.
A1  - Timshel, Pascal N.
A1  - Trzaskowski, Maciej
A1  - Vlaming, Ronald de
A1  - Zünd, Christian L.
A1  - Bao, Yanchun
A1  - Buzdugan, Laura
A1  - Caplin, Ann H.
A1  - Chen, Chia-Yen
A1  - Eibich, Peter
A1  - Fontanillas, Pierre
A1  - Gonzalez, Juan R.
A1  - Joshi, Peter K.
A1  - Karhunen, Ville
A1  - Kleinman, Aaron
A1  - Levin, Remy Z.
A1  - Lill, Christina M.
A1  - Meddens, Gerardus A.
A1  - Muntané, Gerard
A1  - Sanchez-Roige, Sandra
A1  - Rooij, Frank J. van
A1  - Taskesen, Erdogan
A1  - Wu, Yang
A1  - Zhang, Futao
A1  - Auton, Adam
A1  - Boardman, Jason D.
A1  - Clark, David W.
A1  - Conlin, Andrew
A1  - Dolan, Conor C.
A1  - Fischbacher, Urs
A1  - Groenen, Patrick J. F.
A1  - Harris, Kathleen Mullan
A1  - Hasler, Gregor
A1  - Hofman, Albert
A1  - Ikram, Mohammad A.
A1  - Jain, Sonia
A1  - Karlsson, Robert
A1  - Kessler, Ronald C.
A1  - Kooyman, Maarten
A1  - Mackillop, James
A1  - Männikkö, Minna
A1  - Morcillo-Suarez, Carlos
A1  - McQueen, Matthew B.
A1  - Schmidt, Klaus M.
A1  - Smart, Melissa C.
A1  - Sutter, Matthias
A1  - Thurik, A. Roy
A1  - Uitterlinden, Andre G.
A1  - White, Jon
A1  - Wit, Harriet de
A1  - Yang, Jian
A1  - Bertram, Lars
A1  - Boomsma, Dorret I.
A1  - Esko, Tõnu
A1  - Fehr, Ernst
A1  - Hinds, David A.
A1  - Johannesson, Magnus
A1  - Kumari, Meena
A1  - Laibson, David
A1  - Magnusson, Patrik K. E.
A1  - Meyer, Michelle N.
A1  - Navarro, Arcadi
A1  - Palmer, Abraham A.
A1  - Pers, Tune H.
A1  - Posthuma, Danielle
A1  - Schunk, Daniel
A1  - Stein, Murray B.
A1  - Svento, Rauli
A1  - Tiemeier, Henning
A1  - Timmers, Paul R. H. J.
A1  - Turley, Patrick
A1  - Ursano, Robert J.
A1  - Wagner, Gert G.
A1  - Wilson, James F.
A1  - Gratten, Jacob
A1  - Lee, James J.
A1  - Cesarini, David
A1  - Benjamin, Daniel J.
A1  - Koellinger, Philipp D.
A1  - Beauchamp, Jonathan P.
SP  - 245
EP  - 257
VL  - 51
IS  - 2
N2  - Humans vary substantially in their willingness to take risks. In a combined sample of over 1 million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky behaviors in the driving, drinking, smoking, and sexual domains. Across all GWAS, we identified hundreds of associated loci, including 99 loci associated with general risk tolerance. We report evidence of substantial shared genetic influences across risk tolerance and the risky behaviors: 46 of the 99 general risk tolerance loci contain a lead SNP for at least one of our other GWAS, and general risk tolerance is genetically correlated ([Formula: see text] ~ 0.25 to 0.50) with a range of risky behaviors. Bioinformatics analyses imply that genes near SNPs associated with general risk tolerance are highly expressed in brain tissues and point to a role for glutamatergic and GABAergic neurotransmission. We found no evidence of enrichment for genes previously hypothesized to relate to risk tolerance.<p />  <p>Language: en</p>
LA  - en
SN  - 1061-4036
UR  - http://dx.doi.org/10.1038/s41588-018-0309-3
ID  - ref1
ER  -