TY  - JOUR
PY  - 2019//
TI  - Chronic traumatic encephalopathy pathology after shotgun injury to the brain
JO  - Journal of forensic sciences
A1  - Tribett, Taylor
A1  - Erskine, Brittany
A1  - Bailey, Kristi
A1  - Brown, Theodore
A1  - Castellani, Rudy J.
SP  - 1248
EP  - 1252
VL  - 64
IS  - 4
N2  - Chronic traumatic encephalopathy (CTE) was initially conceptualized in boxers, but has extended to other athletes in recent years, albeit with limited clinical correlations. It is often asserted that CTE pathology represents the substrate for progressive neurodegenerative disease. We report the case of a shotgun injury to the brain with 42-year survival and no neurological disease progression until shortly before death. The decedent had no other traumatic brain injury (TBI) exposure and did not play football or other high energy collision sport. Neuropathological examination confirmed tissue damage, but additionally demonstrated localized patterns of phosphorylated tau (p-tau) meeting criteria for CTE pathology. P-tau and TDP-43 deposits within marginal tissue of damaged brain were also present focally. No amyloid-β (Aβ) deposits were present. These findings indicate that CTE pathology may occur following a single, severe TBI.<br><br>© 2019 American Academy of Forensic Sciences.<p />  <p>Language: en</p>
LA  - en
SN  - 0022-1198
UR  - http://dx.doi.org/10.1111/1556-4029.14001
ID  - ref1
ER  -