TY  - JOUR
PY  - 2019//
TI  - Prevalence of potentially clinically significant MRI findings in athletes with and without sport-related concussion
JO  - Journal of neurotrauma
A1  - Klein, Andrew P.
A1  - Tetzlaff, Julie E.
A1  - Bonis, Joshua M.
A1  - Nelson, Lindsay D.
A1  - Mayer, Andrew
A1  - Huber, Daniel L.
A1  - Harezlak, Jaroslaw
A1  - Mathews, Vince P.
A1  - Ulmer, John L.
A1  - Sinson, Grant P.
A1  - Nencka, Andrew S.
A1  - Koch, Kevin M.
A1  - Wu, Yu-Chien
A1  - Saykin, Andrew J.
A1  - Difiori, John P.
A1  - Giza, Christopher C.
A1  - Goldman, Joshua
A1  - Guskiewicz, Kevin K.
A1  - Mihalik, Jason
A1  - Duma, Stefan M.
A1  - Rowson, Steven
A1  - Brooks, Alison
A1  - Broglio, Steven P.
A1  - McAllister, Thomas
A1  - McCrea, Michael
A1  - Meier, Timothy
SP  - 1776
EP  - 1785
VL  - 36
IS  - 11
N2  - Previous studies have shown that mild traumatic brain injury (mTBI) can cause abnormalities in clinically relevant MRI sequences. No large-scale study, however, has prospectively assessed this in athletes with sport-related concussion (SRC). The goal of the current study was to characterize and compare the prevalence of acute, trauma-related MRI findings and clinically significant, non-specific MRI findings in athletes with and without SRC. College and high-school athletes were prospectively enrolled and participated in scanning sessions between January 2015 through August 2017. Concussed contact sport athletes (n=138, 14 F, 19.51.6 years) completed up to four scanning sessions following SRC. Non-concussed contact (n=135, 15 F, 19.71.6) and non-contact athletes (n=96, 15 F, 20.01.7) completed similar scanning sessions and served as controls. Board certified neuroradiologists, blinded to SRC status, reviewed T1-weighted, T2-weighted Fluid Attenuated Inversion Recovery (FLAIR), T2*-weighted, and T2-weighted images for acute (i.e., injury-related) or non-acute findings that prompted recommendation for clinical follow-up. Concussed athletes were more likely to have MRI findings relative to contact (30.4% vs. 15.6%, OR=2.32, p=0.01) and non-contact control athletes (19.8%, OR=2.11, p=0.04). Female athletes were more likely to have MRI findings than males (43.2% vs. 19.4%, OR=2.62, p=0.01). One athlete with SRC had an acute, injury-related finding; group differences were largely driven by increased rate of non-specific white matter hyperintensities in concussed athletes. This prospective, large-scale study demonstrates that <1% of SRCs are associated with acute injury findings on qualitative structural MRI, providing empirical support for clinical guidelines that do not recommend use of MRI following SRC.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2018.6055
ID  - ref1
ER  -