TY  - JOUR
PY  - 2019//
TI  - High-sensitivity C-reactive protein: retrospective study of potential blood biomarker of inflammation in acute mild traumatic brain injury
JO  - Journal of head trauma rehabilitation
A1  - Shetty, Teena
A1  - Cogsil, Taylor
A1  - Dalal, Aashka
A1  - Kim, Esther
A1  - Halvorsen, Kristin
A1  - Cummings, Kelianne
A1  - Nguyen, Joseph T.
SP  - E28
EP  - E36
VL  - 34
IS  - 3
N2  - OBJECTIVE: A panel of biomarkers is needed to definitively diagnose mild traumatic brain injury (mTBI). There is a clear role for the inclusion of an inflammatory biomarker. This study looked to find a relationship between high sensitivity C-reactive protein (hsCRP), an inflammatory biomarker, and mTBI. SETTING: Neurology department of high-volume tertiary orthopedic hospital. PARTICIPANTS: Individuals diagnosed with mTBI (n = 311, age 21 ± 12 years, 53% female). <br><br>DESIGN: Retrospective cohort study. MAIN MEASURES: hsCRP levels; postconcussive symptoms; demographics. <br><br>RESULTS: Continuous hsCRP levels were transformed into quartiles, as defined by less than 0.200 mg/L for quartile 1 (Q1); 0.200 to 0.415 mg/L for quartile 2 (Q2); 0.415 to 1.100 mg/L for quartile 3 (Q3); and greater than 1.100 mg/L for quartile 4 (Q4). Mean hsCRP was elevated in the cohort of individuals who presented within 1 week of injury and was found to significantly decrease between the first visit and 4 weeks postinjury (P =.016). Initial hsCRP level was positively correlated with age (r = 0.163, P =.004), and age significantly increased between quartiles (P =.013). Patients with increased age (odds ratio: 3.48) and those who endorsed headache (odds ratio: 3.48) or fatigue (odds ratio: 2.16) were significantly associated with increased risk of having an hsCRP level in Q4. <br><br>CONCLUSION: hsCRP may be a viable addition to acute and longitudinal biomarker panels for diagnosis and prognosis of mTBI.<p />  <p>Language: en</p>
LA  - en
SN  - 0885-9701
UR  - http://dx.doi.org/10.1097/HTR.0000000000000450
ID  - ref1
ER  -