TY  - JOUR
PY  - 2018//
TI  - Blast-induced brain injury in rats leads to transient vestibulomotor deficits and persistent orofacial pain
JO  - Brain injury
A1  - Studlack, Paige E.
A1  - Keledjian, Kaspar
A1  - Farooq, Tayyiaba
A1  - Akintola, Titilola
A1  - Gerzanich, Volodymyr
A1  - Simard, J. Marc
A1  - Keller, Asaf
SP  - 1866
EP  - 1878
VL  - 32
IS  - 13-14
N2  - Blast-induced traumatic brain injury (blast-TBI) is associated with vestibulomotor dysfunction, persistent post-traumatic headaches and post-traumatic stress disorder, requiring extensive treatments and reducing quality-of-life. Treatment and prevention of these devastating outcomes require an understanding of their underlying pathophysiology through studies that take advantage of animal models. Here, we report that cranium-directed blast-TBI in rats results in signs of pain that last at least 8 weeks after injury. These occur without significantly elevated behavioural markers of anxiety-like conditions and are not associated with glial up-regulation in sensory thalamic nuclei. These injuries also produce transient vestibulomotor abnormalities that resolve within 3 weeks of injury. Thus, blast-TBI in rats recapitulates aspects of the human condition.<p />  <p>Language: en</p>
LA  - en
SN  - 0269-9052
UR  - http://dx.doi.org/10.1080/02699052.2018.1536282
ID  - ref1
ER  -