TY  - JOUR
PY  - 2019//
TI  - Role of Nogo receptor-1 for recovery of balance, cognition and emotion after mild traumatic brain injury in mice
JO  - Journal of neurotrauma
A1  - Lai, Jing-Huei
A1  - Karlsson, Tobias E.
A1  - Wu, John Chung-Che
A1  - Huang, Chi-Zong
A1  - Chen, Yen-Hua
A1  - Kang, Shuo-Jhen
A1  - Brodin, Alvin T. S.
A1  - Hoffer, B. J.
A1  - Olson, Lars
A1  - Chiang, Yung-Hsaio
A1  - Chen, Kai-Yun
SP  - 1054
EP  - 1059
VL  - 36
IS  - 7
N2  - Mild traumatic brain injury (mTBI) constitutes 75~90% of all TBI cases and causes various physical, cognitive, emotional, and other psychological symptoms. Nogo receptor 1 (NgR1) is a regulator of structural brain plasticity during development and in adulthood. Here we used mice that, in the absence of doxycycline, overexpress NgR1 in forebrain neurons (MemoFlex) to determine the role of NgR1 in recovery from mTBI with respect to balance, cognition, memory and emotion. We compared wildtype (WT), MemoFlex and MemoFlex + doxycycline mice to the same three groups subjected to mTBI. mTBI was induced by a controlled 30g weight drop. We found that inability to down-regulate NgR1 significantly impairs recovery from mTBI-induced impairments. When the NgR1 transgene was turned off, recovery was similar to that of WT mice. The results suggest that ability to regulate NgR1 signaling is needed for optimal recovery of motor coordination and balance, spatial memory, cognition and emotional functions after mTBI.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2018.5949
ID  - ref1
ER  -