TY  - JOUR
PY  - 2018//
TI  - Adverse childhood experiences, epigenetic measures, and obesity in youth
JO  - Journal of pediatrics
A1  - Kaufman, Joan
A1  - Montalvo-Ortiz, Janitza L.
A1  - Holbrook, Hannah
A1  - O'Loughlin, Kerry
A1  - Orr, Catherine
A1  - Kearney, Catherine
A1  - Yang, Bao-Zhu
A1  - Wang, Tao
A1  - Zhao, Hongyu
A1  - Althoff, Robert
A1  - Garavan, Hugh
A1  - Gelernter, Joel
A1  - Hudziak, James
SP  - 150
EP  - 156.e3
VL  - 202
IS  - 
N2  - OBJECTIVE: To determine if measures of adverse childhood experiences and DNA methylation relate to indices of obesity in youth. STUDY DESIGN: Participants were derived from a cohort of 321 8 to 15-year-old children recruited for an investigation examining risk and resilience and psychiatric outcomes in maltreated children. Assessments of obesity were collected as an add-on for a subset of 234 participants (56% female; 52% maltreated). Illumina arrays were used to examine whole genome epigenetic predictors of obesity in saliva DNA. For analytic purposes, the cohort analyzed in the first batch comprised the discovery sample (n = 160), and the cohort analyzed in the second batch the replication sample (n = 74). <br><br>RESULTS: After controlling for race, sex, age, cell heterogeneity, 3 principal components, and whole genome testing, 10 methylation sites were found to interact with adverse childhood experiences to predict cross-sectional measures of body mass index, and an additional 6 sites were found to exert a main effect in predicting body mass index (P < 5.0 × 10<sup>-7</sup>, all comparisons). Eight of the methylation sites were in genes previously associated with obesity risk (eg, PCK2, CxCl10, BCAT1, HID1, PRDM16, MADD, PXDN, GALE), with several of the findings from the discovery data set replicated in the second cohort. <br><br>CONCLUSIONS: This study lays the groundwork for future longitudinal studies to elucidate these mechanisms further and identify novel interventions to alleviate the health burdens associated with early adversity.<br><br>Copyright © 2018 Elsevier Inc. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0022-3476
UR  - http://dx.doi.org/10.1016/j.jpeds.2018.06.051
ID  - ref1
ER  -