TY  - JOUR
PY  - 2018//
TI  - Cerebral hemodynamics after transcranial direct current stimulation (tDCS) in patients with consequences of traumatic brain injury
JO  - Advances in experimental medicine and biology
A1  - Trofimov, Alexey O.
A1  - Kalentiev, George
A1  - Karelsky, Michael
A1  - Ksenofontova, Cristina
A1  - Ruzavina, Alevtina
A1  - Yuriev, Michail
A1  - Bragin, Denis E.
SP  - 59
EP  - 62
VL  - 1072
IS  - 
N2  - In recent years, hopes for better treatment of traumatic brain injury (TBI) have focused on non-pharmacologic transcranial electrical brain stimulation; however, studies of perfusion changes after stimulation are few and contradictory. Therefore, the aim of this study was to assess cerebral perfusion after high-definition transcranial direct current stimulation (HD-tDCS) in patients with posttraumatic encephalopathy (PTE). <br><br>METHODS: Twenty patients with PTE (16 men and 4 women, aged 35.5 ± 14.8 years) underwent perfusion computed tomography (PCT), followed by anodal HD-tDCS and post-stimulation tomography at 21 days after TBI. The Westermark perfusion maps were constructed and quantitative perfusion parameters calculated. Significance was preset to P < 0.05. <br><br>RESULTS: Qualitative analysis revealed that all patients had areas with reduced cerebral blood flow (CBF) and increased average mean transit time (MTT). HD-tDCS was accompanied by a significant decrease in the number of zones of both hypoperfusion and ischemia (p < 0.05). Quantitative analysis showed that, in all patients, HD-tDCS caused a significant increase in CBF (p < 0.001), cerebral blood volume (CBV) (p < 0.01) and MTT shortening (p < 0.05) in the frontotemporal region on the anode side. In the basal ganglia, a significant increase in CBF was found only in the five patients in whom this was initially reduced (p < 0.01) and only with an anode placed on the same side. <br><br>CONCLUSIONS: In patients with complications due to PTE TBI, HD-tDCS causes a significant increase in CBV, CBF and a decrease in the average MTT, suggesting better oxygen delivery to tissue.<p />  <p>Language: en</p>
LA  - en
SN  - 0065-2598
UR  - http://dx.doi.org/10.1007/978-3-319-91287-5_10
ID  - ref1
ER  -