TY  - JOUR
PY  - 2019//
TI  - Decreases in white matter integrity of ventrolimbic pathway linked to posttraumatic stress disorder in mild traumatic brain injury
JO  - Journal of neurotrauma
A1  - Santhanam, Priya
A1  - Teslovich, Theresa
A1  - Wilson, Steffanie H.
A1  - Yeh, Ping-Hong
A1  - Oakes, Terrence R.
A1  - Weaver, Lindell
SP  - 1093
EP  - 1098
VL  - 36
IS  - 7
N2  - Post-traumatic stress disorder (PTSD) is commonly observed in military service members with mild traumatic brain injury (mTBI); however, the relationship between mTBI and PTSD is complex and not well-understood. The present study aims to elucidate a link between the degree of alteration in limbic system-related white matter tracts and PTSD symptoms in an mTBI population. Diffusion tensor imaging with probabilistic tractography of the fronto-limbic pathways revealed decreased white matter integrity in the uncinate fasciculus in those with comorbid mTBI and PTSD (n=34), relative to those with only mTBI (n=35). Additionally, fractional anisotropy and radial diffusivity measures in the bilateral uncinate fasciculus correlated with PTSD checklist (PCL-C) scores, and primarily within the avoidance and re-experiencing domains. <br><br>FINDINGS from this study suggest the degree of traumatic injury within the limbic system could be directly related to post-traumatic stress and post-concussive symptoms, with disrupted white matter leading to significant PTSD outcomes.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2017.5541
ID  - ref1
ER  -