TY  - JOUR
PY  - 2019//
TI  - Aggressive behaviour in childhood and adolescence: the role of smoking during pregnancy, evidence from four twin cohorts in the EU-ACTION consortium
JO  - Psychological medicine
A1  - Malanchini, Margherita
A1  - Smith-Woolley, Emily
A1  - Ayorech, Ziada
A1  - Rimfeld, Kaili
A1  - Krapohl, Eva
A1  - Vuoksimaa, Eero
A1  - Korhonen, Tellervo
A1  - Bartels, Meike
A1  - van Beijsterveldt, Toos C. E. M.
A1  - Rose, Richard J.
A1  - Lundström, Sebastian
A1  - Anckarsäter, Henrik
A1  - Kaprio, Jaakko
A1  - Lichtenstein, Paul
A1  - Boomsma, Dorret I.
A1  - Plomin, Robert
SP  - 646
EP  - 654
VL  - 49
IS  - 4
N2  - BACKGROUND: Maternal smoking during pregnancy (MSDP) has been linked to offspring's externalizing problems. It has been argued that socio-demographic factors (e.g. maternal age and education), co-occurring environmental risk factors, or pleiotropic genetic effects may account for the association between MSDP and later outcomes. This study provides a comprehensive investigation of the association between MSDP and a single harmonized component of externalizing: aggressive behaviour, measured throughout childhood and adolescence. <br><br>METHODS: Data came from four prospective twin cohorts - Twins Early Development Study, Netherlands Twin Register, Childhood and Adolescent Twin Study of Sweden, and FinnTwin12 study - who collaborate in the EU-ACTION consortium. Data from 30 708 unrelated individuals were analysed. Based on item level data, a harmonized measure of aggression was created at ages 9-10; 12; 14-15 and 16-18. <br><br>RESULTS: MSDP predicted aggression in childhood and adolescence. A meta-analysis across the four samples found the independent effect of MSDP to be 0.4% (r = 0.066), this remained consistent when analyses were performed separately by sex. All other perinatal factors combined explained 1.1% of the variance in aggression across all ages and samples (r = 0.112). Paternal smoking and aggressive parenting strategies did not account for the MSDP-aggression association, consistent with the hypothesis of a small direct link between MSDP and aggression. <br><br>CONCLUSIONS: Perinatal factors, including MSDP, account for a small portion of the variance in aggression in childhood and adolescence. Later experiences may play a greater role in shaping adolescents' aggressive behaviour.<p />  <p>Language: en</p>
LA  - en
SN  - 0033-2917
UR  - http://dx.doi.org/10.1017/S0033291718001344
ID  - ref1
ER  -