TY  - JOUR
PY  - 2018//
TI  - Sleep, sleep disorders, and circadian health following mild traumatic brain injury: review and research agenda
JO  - Journal of neurotrauma
A1  - Manley, Geoffrey
A1  - Markowitz, Amy
A1  - Badjatia, Neeraj
A1  - Albrecht, Jennifer S.
A1  - Stocker, Ryan
A1  - Scharf, Steven
A1  - McKeon, Ashlee
A1  - Lettieri, Christopher
A1  - Williams, Scott
A1  - Smith, Michael T.
A1  - Germain, Anne
A1  - Schnyer, David M.
A1  - Wickwire, Emerson
SP  - 2615
EP  - 2631
VL  - 35
IS  - 22
N2  - A rapidly expanding scientific literature supports the frequent co-occurrence of sleep and circadian disturbances following mild traumatic brain injury (mTBI). Although many questions remain unanswered, the preponderance of evidence suggests that sleep and circadian disorders can result from mTBI. Among those with mTBI, sleep disturbances and clinical sleep and circadian disorders contribute to the morbidity and long-term sequelae across domains of functional outcomes and quality of life. Specifically, along with deterioration of neurocognitive performance, insufficient and disturbed sleep can precede, exacerbate, or perpetuate many of the other common sequelae of mTBI, including depression, post-traumatic stress disorder, and chronic pain. Further, sleep and mTBI share neurophysiologic and neuroanatomic mechanisms that likely bear directly on success of rehabilitation following mTBI. For these reasons, focus on disturbed sleep as a modifiable treatment target has high likelihood of improving outcomes in mTBI. Here, we review relevant literature and present a research agenda to 1) advance understanding of the reciprocal relationships between sleep and circadian factors and mTBI sequelae and 2) advance rapidly the development of sleep-related treatments in this population.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2017.5243
ID  - ref1
ER  -