TY  - JOUR
PY  - 2018//
TI  - Neuromodulatory treatments for alcohol use disorder: a review
JO  - Brain sciences
A1  - Salib, Anne-Mary N.
A1  - Ho, Allen L.
A1  - Sussman, Eric S.
A1  - Pendharkar, Arjun V.
A1  - Halpern, Casey H.
SP  - e8060095
EP  - e8060095
VL  - 8
IS  - 6
N2  - Alcohol use disorder (AUD) is a prevalent condition characterized by chronic alcohol-seeking behaviors and has become a significant economic burden with global ramifications on public health. While numerous treatment options are available for AUD, many are unable to sustain long-term sobriety. The nucleus accumbens (NAcc) upholds an integral role in mediating reward behavior and has been implicated as a potential target for deep brain stimulation (DBS) in the context of AUD. DBS is empirically thought to disrupt pathological neuronal synchrony, a hallmark of binge behavior. Pre-clinical animal models and pilot human clinical studies utilizing DBS for the treatment of AUD have shown promise for reducing alcohol-related cravings and prolonging abstinence. In this review, we outline the various interventions available for AUD, and the translational potential DBS has to modulate functionality of the NAcc as a treatment for AUD.<p />  <p>Language: en</p>
LA  - en
SN  - 2076-3425
UR  - http://dx.doi.org/10.3390/brainsci8060095
ID  - ref1
ER  -