TY  - JOUR
PY  - 2018//
TI  - What can we learn from diffusion tensor imaging from a large traumatic brain injury cohort? White matter integrity and its relationship with outcome
JO  - Journal of neurotrauma
A1  - Castaño-Leon, Ana M.
A1  - Cicuendez, Marta
A1  - Navarro, Blanca
A1  - Munarriz, Pablo M.
A1  - Cepeda, Santiago
A1  - Paredes, Igor
A1  - Hilario, Amaya
A1  - Ramos, Ana
A1  - Gomez, Pedro Antonio
A1  - Lagares, Alfonso
SP  - 2365
EP  - 2376
VL  - 35
IS  - 20
N2  - Traumatic axonal injury (TAI) contributes significantly to mortality and morbidity after traumatic brain injury (TBI) but its identification is still a diagnostic challenge because of the limitations of conventional imaging techniques to characterized it. Diffusion tensor imaging (DTI) can indirectly identify areas of damaged white matter (WM) integrity by detecting water molecules diffusion alterations. Therefore, DTI may improve detection and description of TAI lesions after TBI. We have obtained DTI data from 217 patients with moderate to severe TBI acquired at median 19 days after TBI were and patient DTI metrics were compared with data obtained from 58 age-matched healthy controls. Region of interest (ROI) method was applied to obtain mean Fractional Anisotropy (FA) value in 28 WM fiber bundles susceptible to TAI. Our main results were that when we compared with controls, patients regardless of TBI severity showed significantly reduced mean FA in almost all ROI measured. We found statistically significant correlation between FA metrics and some demographic, clinical and conventional imaging characteristics. Additionally, these FA metrics were highly associated with outcome assessed at hospital discharge and at 6 and 12 months after TBI. We conclude that FA reduction in the subacute stage after TBI assessed by DTI may be a useful prognostic factor for long-term unfavourable outcome.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2018.5691
ID  - ref1
ER  -