TY  - JOUR
PY  - 2018//
TI  - Psychotic-like experiences in pre-adolescence: what precedes the antecedent symptoms of severe mental illness?
JO  - Acta psychiatrica Scandinavica
A1  - Bolhuis, K.
A1  - Koopman-Verhoeff, M. E.
A1  - Blanken, L. M. E.
A1  - Cibrev, D.
A1  - Jaddoe, V. W. V.
A1  - Verhulst, F. C.
A1  - Hillegers, M. H. J.
A1  - Kushner, S. A.
A1  - Tiemeier, H.
SP  - 15
EP  - 25
VL  - 138
IS  - 1
N2  - OBJECTIVE: Adolescent psychotic-like experiences predict the onset of psychosis, but also predict subsequent non-psychotic disorders. Therefore, it is crucial to better understand the aetiology of psychotic-like experiences. This study examined whether (a) child emotional and behavioural problems at 3 and 6 years, or (b) childhood adversities were associated with psychotic-like experiences at age 10 years. <br><br>METHOD: This prospective study was embedded in the Generation R Study; 3984 children (mean age 10 years) completed a psychotic-like experiences questionnaire. Mothers reported problems of their child at ages 3, 6 and 10 years. Additionally, mothers were interviewed about their child's adversities. <br><br>RESULTS: Psychotic-like experiences were endorsed by ~20% of children and predicted by both emotional and behavioural problems at 3 years (e.g. emotional-reactive problems: OR<sub>adjusted</sub> = 1.10, 95% CI: 1.06-1.15, aggressive behaviour: OR<sub>adjusted</sub> = 1.03, 95% CI: 1.02-1.05) and 6 years (e.g. anxious/depressed problems: OR<sub>adjusted</sub> = 1.11, 95% CI: 1.06-1.15, aggressive behaviour: OR<sub>adjusted</sub> = 1.04, 95% CI: 1.04-1.05). Childhood adversities were associated with psychotic-like experiences (>2 adversities: OR<sub>adjusted</sub> = 2.24, 95% CI: 1.72-2.92), which remained significant after adjustment for comorbid psychiatric problems. <br><br>CONCLUSION: This study demonstrated associations between early adversities, childhood emotional and behavioural problems and pre-adolescent psychotic-like experiences, which will improve the understanding of children at increased risk of severe mental illness.<br><br>© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.<p />  <p>Language: en</p>
LA  - en
SN  - 0001-690X
UR  - http://dx.doi.org/10.1111/acps.12891
ID  - ref1
ER  -