TY  - JOUR
PY  - 2018//
TI  - A hypothalamic circuit for the circadian control of aggression
JO  - Nature neuroscience
A1  - Todd, William D.
A1  - Fenselau, Henning
A1  - Wang, Joshua L.
A1  - Zhang, Rong
A1  - Machado, Natalia L.
A1  - Venner, Anne
A1  - Broadhurst, Rebecca Y.
A1  - Kaur, Satvinder
A1  - Lynagh, Timothy
A1  - Olson, David P.
A1  - Lowell, Bradford B.
A1  - Fuller, Patrick M.
A1  - Saper, Clifford B.
SP  - 717
EP  - 724
VL  - 21
IS  - 5
N2  - 'Sundowning' in dementia and Alzheimer's disease is characterized by early-evening agitation and aggression. While such periodicity suggests a circadian origin, whether the circadian clock directly regulates aggressive behavior is unknown. We demonstrate that a daily rhythm in aggression propensity in male mice is gated by GABAergic subparaventricular zone (SPZ<sup>GABA</sup>) neurons, the major postsynaptic targets of the central circadian clock, the suprachiasmatic nucleus. Optogenetic mapping revealed that SPZ<sup>GABA</sup> neurons receive input from vasoactive intestinal polypeptide suprachiasmatic nucleus neurons and innervate neurons in the ventrolateral part of the ventromedial hypothalamus (VMH), which is known to regulate aggression. Additionally, VMH-projecting dorsal SPZ neurons are more active during early day than early night, and acute chemogenetic inhibition of SPZ<sup>GABA</sup> transmission phase-dependently increases aggression. Finally, SPZ<sup>GABA</sup>-recipient central VMH neurons directly innervate ventrolateral VMH neurons, and activation of this intra-VMH circuit drove attack behavior. Altogether, we reveal a functional polysynaptic circuit by which the suprachiasmatic nucleus clock regulates aggression.<p />  <p>Language: en</p>
LA  - en
SN  - 1097-6256
UR  - http://dx.doi.org/10.1038/s41593-018-0126-0
ID  - ref1
ER  -