TY  - JOUR
PY  - 2018//
TI  - Synthesis and explosion hazards of 4-azido-L-phenylalanine
JO  - Journal of organic chemistry
A1  - Richardson, Mark B.
A1  - Brown, Derek B.
A1  - Vasquez, Carlos
A1  - Ziller, Joseph W.
A1  - Johnston, Kevin M.
A1  - Weiss, Gregory A.
SP  - 4525
EP  - 4536
VL  - 83
IS  - 8
N2  - A reliable, scalable, cost-effective, and chromatography-free synthesis of 4-azido-L-phenylalanine beginning from L-phenylalanine is described. Investigations into the safety of the synthesis reveal that the Ullman-like Cu(I)-catalyzed azidation step does not represent a significant risk. The isolated 4-azido-L-phenylalanine product, however, exhibits previously undocumented explosive characteristics.<p />  <p>Language: en</p>
LA  - en
SN  - 0022-3263
UR  - http://dx.doi.org/10.1021/acs.joc.8b00270
ID  - ref1
ER  -