TY  - JOUR
PY  - 2018//
TI  - Traumatic brain injury: classification, models and markers
JO  - Biochemistry and cell biology
A1  - Najem, Dema
A1  - Rennie, Kerry
A1  - Ribecco, Maria
A1  - Ly, Dao
A1  - Haukenfrers, Julie
A1  - Liu, Qing
A1  - Nzau, Munyao
A1  - Fraser, Douglas
A1  - Bani, Mahmud
SP  - 391
EP  - 406
VL  - 96
IS  - 4
N2  - Traumatic brain injury (TBI) is a leading cause of morbidity and mortality worldwide. Due to its high incidence rate and often long-term sequelae, TBI contributes significantly to increasing costs of medicare expenditures annually. Unfortunately, advances in the field have been stifled by patient and injury heterogeneity that pose a major challenge in TBI prevention, diagnosis and treatment. In this review, we briefly discuss the causes of TBI, followed by its prevalence, classification and pathophysiology. The current imaging detection methods and animal models used to study brain injury are examined. We discuss the potential use of molecular markers in detecting and monitoring the progression of TBI, with particular emphasis on microRNAs as a novel class of molecular modulators of injury and its repair in the neural tissue.<p />  <p>Language: en</p>
LA  - en
SN  - 0829-8211
UR  - http://dx.doi.org/10.1139/bcb-2016-0160
ID  - ref1
ER  -