TY  - JOUR
PY  - 2018//
TI  - The impact of COMT and childhood maltreatment on suicidal behaviour in affective disorders
JO  - Scientific reports
A1  - Bernegger, Alexandra
A1  - Kienesberger, Klemens
A1  - Carlberg, Laura
A1  - Swoboda, Patrick
A1  - Ludwig, Birgit
A1  - Koller, Romina
A1  - Inaner, Michelle
A1  - Zotter, Melanie
A1  - Kapusta, Nestor
A1  - Aigner, Martin
A1  - Haslacher, Helmuth
A1  - Kasper, Siegfried
A1  - Schosser, Alexandra
SP  - e692
EP  - e692
VL  - 8
IS  - 1
N2  - The inconsistent findings on the association between COMT (catecholamine-O-methyl-transferase) and suicidal behaviour gave reason to choose a clear phenotype description of suicidal behaviour and take childhood maltreatment as environmental factor into account. The aim of this candidate-gene-association study was to eliminate heterogeneity within the sample by only recruiting affective disorder patients and find associations between COMT polymorphisms and defined suicidal phenotypes. In a sample of 258 affective disorder patients a detailed clinical assessment (e.g. CTQ, SCAN, HAMD, SBQ-R, VI-SURIAS, LPC) was performed. DNA of peripheral blood samples was genotyped using TaqMan® SNP Genotyping Assays. We observed that the haplotype GAT of rs737865, rs6269, rs4633 is significantly associated with suicide attempt (p = 0.003 [pcorr = 0.021]), and that there is a tendency towards self-harming behaviour (p = 0.02 [pcorr = 0.08]) and also NSSI (p = 0.03 [pcorr = 0.08]), though the p values did not resist multiple testing correction. The same effect we observed with the 4-marker slide window haplotype, GATA of rs737865, rs6269, rs4633, rs4680 (p = 0.009 [pcorr = 0.045]). The findings support an association between the COMT gene and suicidal behaviour phenotypes with and without childhood maltreatment as environmental factor.<p />  <p>Language: en</p>
LA  - en
SN  - 2045-2322
UR  - http://dx.doi.org/10.1038/s41598-017-19040-z
ID  - ref1
ER  -