TY - JOUR PY - 2018// TI - Neuroimmunology of traumatic brain injury: a longitudinal study of interdependency of inflammatory markers and heart rate variability in severe traumatic brain injury JO - Journal of neurotrauma A1 - Deepika, Akhil A1 - Devi, Bhagavatula Indira A1 - Shukla, Dhaval P. A1 - Sathyaprabla, Talakad N. A1 - Christopher, Rita A1 - Ramesh, Shruthi S. SP - 1124 EP - 1131 VL - 35 IS - 10 N2 - The purpose of the present study is to evaluate the inter-dependency between the electrophysiological (Heart rate variability) and inflammatory markers in traumatic brain injury (TBI) patients and the outcome in patients with severe TBI. A prospective exploratory study was done with a sample size of 89 severe traumatic brain injury patients. The Heart rate variability of these patients was recorded using a telemetric device BioHarness® (Zephyr technologies). The recordings were made on day 1 of the patients' admission into the ICU followed by serial recordings on Day 3 and day 10. Serum samples of the patients were also collected on these days. They were analyzed for the IL-1β, IL-6, IL-10 and TNF-α using ELISA kits. The outcome assessment was done based on Disability Rating Scale (DRS) values at discharge and Glasgow Outcome Scale Extended (GOSE) values observed at the sixth month post trauma. The data set was analysed by grouping the patients on the basis of mortality and their outcome. In the present study, it was evidenced that there was significant subclinical autonomic dysfunction in patients with severe TBI. Among the serum cytokines, the levels of IL-10 had significant impact on the outcome. An increase in its levels correlated with the unfavorable outcome. This study highlights the association between the HRV parameters and the immune response. The timely management of both autonomic and immune dysfunction in the patients of severe TBI can have a greater impact in preventing the secondary injury process.

Language: en

LA - en SN - 0897-7151 UR - http://dx.doi.org/10.1089/neu.2017.5151 ID - ref1 ER -