TY  - JOUR
PY  - 2018//
TI  - Decreased number of self-paced saccades in post-concussion syndrome associated with higher symptom burden and reduced white matter integrity
JO  - Journal of neurotrauma
A1  - Taghdiri, Foad
A1  - Chung, Jonathan
A1  - Irwin, Samantha
A1  - Multani, Namita
A1  - Tarazi, Apameh
A1  - Ebraheem, Ahmed
A1  - Khodadadi, Mozhgan
A1  - Goswami, Ruma
A1  - Wennberg, Richard
A1  - Mikulis, David
A1  - Green, Robin Ea
A1  - Davis, Karen
A1  - Tator, Charles
A1  - Eizenman, Moshe
A1  - Tartaglia, Maria Carmela
SP  - 719
EP  - 729
VL  - 35
IS  - 5
N2  - The aim of this study was to examine the potential utility of a self-paced saccadic eye movement as a marker of post-concussion syndrome (PCS) and monitoring the recovery from PCS. Fifty-nine persistently symptomatic participants with at least two concussions performed the self-paced saccade (SPS) task. We evaluated the relationships between the number of SPSs and (i) number of self-reported concussion symptoms, and (ii) integrity of major WM tracts (as measured by fractional anisotropy [FA], and mean diffusivity [MD]) that are directly or indirectly involved in saccadic eye movements and often affected by concussion. These tracts included the uncinate fasciculus (UF), cingulum (Cg) and its three subcomponents (subgenual, retrosplenial, and parahippocampal), superior longitudinal fasciculus (SLF), and corpus callosum (CC). Mediation analyses were carried out to examine whether specific WM tracts (left UF, and left subgenual Cg) mediated the relationship between the number of SPSs and (i) interval from last concussion or (ii) total number of self-reported symptoms. The number of SPSs was negatively correlated with the total number of self-reported symptoms (r=-0.419, p=0.026). The number of SPSs were positively correlated with FA of left UF and left Cg (r=0.421, p=0.013; and r=0.452, p=0.008; respectively). FA of the subgenual subcomponent of the left Cg partially mediated the relationship between the total number of symptoms and the number of SPSs, while FA of the left UF mediated the relationship between interval from last concussion and the number of SPSs. In conclusion, SPS testing, as a fast and objective assessment, may reflect symptom burden in patients with PCS. In addition, since the number of SPSs is associated with the integrity of some WM tracts, it may be useful as a diagnostic biomarker in patients with PCS.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2017.5274
ID  - ref1
ER  -