TY  - JOUR
PY  - 2018//
TI  - Inflammasome: its role in traumatic brain and spinal cord injury
JO  - Journal of cellular physiology
A1  - Mortezaee, Keywan
A1  - Khanlarkhani, Neda
A1  - Beyer, Cordian
A1  - Zendedel, Adib
SP  - 5160
EP  - 5169
VL  - 233
IS  - 7
N2  - Traumatic brain injury (TBI) and spinal cord injury (SCI) are pathological events that lead to neuropathological conditions which have in consequence the initiation of pro-inflammatory cytokine production. Neuroinflammation plays a key role in the secondary phase of both TBI and SCI after initial cell death. Activation of cytoplasmic inflammasome complexes is regarded as the essential step of neuroinflammation and a key trigger for neuronal death called pyroptosis. Inflammasome complexes are involved in activation of caspase-1 which catalyzes the cleavage of pro-interleukins into their active forms (including interleukin-18 (IL-18) and IL-1β). The focus of this article is to discuss the time-course and regulation of inflammasome assembly and activation during TBI and SCI and their targeting in designing therapeutic approaches. We particularly focus on the inflammasomes NLRP1 and NLRP3 which play a pivotal function during TBI and SCI in the central nervous system (CNS). This article is protected by copyright. All rights reserved.<br><br>This article is protected by copyright. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0021-9541
UR  - http://dx.doi.org/10.1002/jcp.26287
ID  - ref1
ER  -