TY  - JOUR
PY  - 2017//
TI  - Respiratory failure following organophosphate poisoning: a literature review
JO  - Curēus
A1  - Giyanwani, Pirthvi Raj
A1  - Zubair, Ujala
A1  - Salam, Osama
A1  - Zubair, Zarafshan
SP  - e1651
EP  - e1651
VL  - 9
IS  - 9
N2  - Organophosphates (OPs) account for a large portion of suicides globally. OP manifests as cholinergic crises, which underlie respiratory failure. There are many pathways by which respiration is inhibited secondary to organophosphate poisoning. These include central as well as peripheral mechanisms, with central mechanisms predominating. We conducted a literature review in June 2017. PubMed, Embase, and Google Scholar were searched for studies that reported acute organophosphate poisoning in humans. In our review, data were collected from studies published during the years 2001 to 2016. The data consisted of 1,996 patients with organophosphate poisoning, of which 491 (24.6%) required ventilatory support secondary to respiratory failure. Treatment offered to OP poisoning patients should focus on its pathophysiology to benefit from the future outcomes. Recent advances direct the need for a central nervous system (CNS) protective strategy for future prevention and treatment of events associated with cholinergic crises.<p />  <p>Language: en</p>
LA  - en
SN  - 2168-8184
UR  - http://dx.doi.org/10.7759/cureus.1651
ID  - ref1
ER  -