TY  - JOUR
PY  - 2017//
TI  - Brain-heart interactions in traumatic brain injury
JO  - Cardiology in review
A1  - El-Menyar, Ayman
A1  - Goyal, Abhishek
A1  - Latifi, Rifat
A1  - Al-Thani, Hassan
A1  - Frishman, William
SP  - 279
EP  - 288
VL  - 25
IS  - 6
N2  - The cardiovascular manifestations associated with nontraumatic head disorders are commonly known. Similar manifestations have been reported in patients with traumatic brain injury (TBI); however, the underlying mechanisms and impact on the patient's clinical outcomes are not well explored. The neurocardiac axis theory and neurogenic stunned myocardium phenomenon could partly explain the brain-heart link and interactions and can thus pave the way to a better understanding and management of TBI. Several observational retrospective studies have shown a promising role for beta-adrenergic blockers in patients with TBI in reducing the overall TBI-related mortality. However, several questions remain to be answered in clinical randomized-controlled trials, including population selection, beta blocker type, dosage, timing, and duration of therapy, while maintaining the optimal mean arterial pressure and cerebral perfusion pressure in patients with TBI.<p />  <p>Language: en</p>
LA  - en
SN  - 1061-5377
UR  - http://dx.doi.org/10.1097/CRD.0000000000000167
ID  - ref1
ER  -