TY  - JOUR
PY  - 2017//
TI  - The impact of BDNF polymorphisms on suicidality in treatment-resistant major depressive disorder: a European multicenter study
JO  - International journal of neuropsychopharmacology
A1  - Schosser, Alexandra
A1  - Carlberg, Laura
A1  - Calati, Raffaella
A1  - Serretti, Alessandro
A1  - Massat, Isabel
A1  - Spindelegger, Christoph
A1  - Linotte, Sylvie
A1  - Mendlewicz, Julien
A1  - Souery, Daniel
A1  - Zohar, Joseph
A1  - Montgomery, Stuart
A1  - Kasper, Siegfried
SP  - 782
EP  - 787
VL  - 20
IS  - 10
N2  - BACKGROUND: Numerous studies have reported associations between the brain-derived neurotrophic factor (BDNF) gene and psychiatric disorders, including suicidal behavior, although with conflicting results. <br><br>METHODS: A total of 250 major depressive disorder patients were collected in the context of a European multicenter resistant depression study and treated with antidepressants at adequate doses for at least 4 weeks. Suicidality was assessed using the Mini International Neuropsychiatric Interview and Hamilton Rating Scale for Depression, and treatment response using the HAM-D. Genotyping was performed for the functional Val66Met polymorphism (rs6265) and 7 additional tagging single nucleotide polymorphisms within the BDNF gene. <br><br>RESULTS: Neither BDNF single markers nor haplotypes were found to be associated with suicide risk and lifetime history of suicide attempts. Gender-specific analyses revealed nonsignificant single marker (rs908867) and haplotypic association with suicide risk in males after multiple testing correction. Analyzing treatment response phenotypes, the functional Val66Met polymorphism as well as rs10501087 showed significant genotypic and haplotypic association with suicide risk in remitters (n=34, 13.6%). <br><br>CONCLUSIONS: Considering the sample size, the present findings need to be replicated in larger samples to confirm or refute a role of BDNF in the investigated suicidal behavior phenotypes.<p />  <p>Language: en</p>
LA  - en
SN  - 1461-1457
UR  - http://dx.doi.org/10.1093/ijnp/pyx028
ID  - ref1
ER  -