TY  - JOUR
PY  - 1982//
TI  - Combined phenytoin and phenobarbital overdose
JO  - Drug intelligence and clinical pharmacy
A1  - Vlasses, P. H.
A1  - Rocci, M. L.
A1  - Koffer, H.
A1  - Ferguson, R. K.
SP  - 487
EP  - 488
VL  - 16
IS  - 6
N2  - A 32-year-old female attempted suicide by consuming large quantities of both phenytoin (P) and phenobarbital (Pb). On hospital admission, serum drug concentrations (SDC), measured by immunoassay, were 46 micrograms/ml for P and 86 micrograms/ml for Pb. The patient remained unconscious, requiring mechanical ventilation, for the next two weeks. Serial SDC demonstrated: (1) continued P absorption over the next five days; (2) different elimination patterns for the two drugs (Pb exhibited first-order elimination while P elimination represented Michaelis-Menten kinetic); and (3) the limited effectiveness of forced alkaline diuresis in lowering Pb serum concentration, though resulting in an episode of pulmonary edema. The patient's clinical status subsequently improved and correlated well with SDC decline into the usual therapeutic range.<p /> <p>Language: en</p>
LA  - en
SN  - 0012-6578
UR  - http://dx.doi.org/
ID  - ref1
ER  -